Targeted nutritional supplementation has been successfully used in multiple clinical settings. Enhanced outcomes have been seen for many years in burn, plastic, ulcer, and reconstructive surgery of head & neck cancer. The rationale for supplementing is based primarily on studies that show an increase in wound breaking strength and collagen formation in these challenging patient populations. Recent studies have also demonstrated improved post-op clinical outcomes in orthopedic trauma and total knee arthroplasty patients.

Preservation of muscle mass, improved ACL graft collagen incorporation  and improved return to functional activity are key variables in a successful ACL reconstruction outcome.