Optimize Athletic Potential: Enhance Recovery and Performance

XR™ was originally formulated by surgeons to aid in surgical recovery based on advances in nutritional sciences. This innovative amino acid blend is designed to target musculoskeletal recovery. Clinically researched ingredients at optimal effective doses, support not only surgical and injury recuperation but also athletic performance. Built upon a solid scientific foundation, incorporating aerospace research, and supported by clinical studies for each ingredient, this unique supplement ensures both safety and efficacy. The XR™ comprehensive approach offers a nutritional strategy designed to optimize and maintain performance while supporting quicker recovery with sports nutrition.

Addressing Athlete Challenges: 

Preserving Muscle Strength and Mass During Recovery

In the face of injury, recovery, or immobilization, XR™ ingredients support preventing muscle and strength loss during periods of inactivity. This can hasten return to sport and functional recovery. (1,2,3,4,5,6)

Stimulating Muscle Growth

XR™ features the innovative MSK Anabolic Complex, specifically formulated to optimize skeletal muscle production. (7,8,25)

Decreasing Metabolic Stress

The ingredients within XR™ work to reduce post-exercise metabolic stress markers; cortisol levels, oxidative stress, and lactate buildup. By addressing these markers, we support and optimize the body's natural recovery mechanisms, promoting improved overall wellness and faster recuperation. (9,10,11)

Easing Delayed Onset Muscle Soreness (DOMS)

Improving athletic performance requires sufficient muscle and tissue recovery. XR™ contains ingredients that have be shown to expedite healing, minimize downtime, support muscle fatigue and reduce duration and magnitude of DOMS*, a symptom of exercise-induced muscle damage that occurs following intense exercise. (12,13)

Minimizing Exercise-Induced Muscle Damage (EIMD)

Intense exercises, especially those involving eccentric muscle contractions, can cause mechanical stress and damage to the muscle's structural components. XR's ingredients have been clinically proven to reduce creatine kinase (CK) breakdown, a marker of exercise-Induced muscle damage (EIMD), compared to a placebo.  (13,14,16)

Optimizing Circulation

Optimal circulation and blood flow are necessary to support intense training and promote tissue healing. XR™'s formulation contains ingredients that have been demonstrated to enhance Nitric Oxide production, leading to  increased blood flow, improved muscle contraction, gas exchange, oxygen kinetics, mitochondrial efficiency and improved muscle contractility. (17,26)

Enhance Athletic Performance

XR™'s comprehensive formulation includes a key combination of amino acids that have been demonstrated to work synergistically to positively impact both aerobic and anaerobic performance parameters. (17,20,27,28,29,30,31)

Faster Return to Functional Activity

XR™ supports a quick return to functional activities by aiding in the preservation of muscle strength and mass during recovery, ultimately expediting rehabilitation and enabling athletes to resume their normal daily and athletic routines swiftly. (3,6,18,19)

Preservation of Muscle Mass During Calorie Deficit

Athletes and active adults often aim to improve or maintain fitness while losing weight through caloric restriction, intermittent fasting, and exercise. However, this can risk lean tissue loss, limiting performance. Research indicates that the BCAA supplements in XR™, when combined with resistance training during a hypocaloric diet, can help maintain lean mass and preserve skeletal muscle performance while reducing fat mass. (21,22,23,24)

Minimize Cognitive Fatigue

The decline in cognitive performance has been shown after intense exercise. XR™'s formulation includes Branched-chain amino acids (BCAA) along with creatine, arginine and L-citrulline which have been shown to alleviate exercise-induced central fatigue and improve cognitive function. (32,33,34,35,36)

References:

  1. Golladay GJ. Nutritional Optimization with Amino Acid Supplementation Aids Recovery After Total Knee Arthroplasty: Commentary on an article by Hideki Ueyama, MD, PhD, et al.: "Perioperative Essential Amino Acid Supplementation Facilitates Quadriceps Muscle Strength and Volume Recovery After TKA. A Double-Blinded Randomized Controlled Trial". J Bone Joint Surg Am. 2023 Mar 1;105(5):e16. doi: 10.2106/JBJS.22.01357. Epub 2023 Mar 1. PMID: 36856694.
  2. Hendrickson NR, Davison J, Glass NA, Wilson ES, Miller A, Leary S, Lorentzen W, Karam MD, Hogue M, Marsh JL, Willey MC. Conditionally Essential Amino Acid Supplementation Reduces Postoperative Complications and Muscle Wasting After Fracture Fixation: A Randomized Controlled Trial. J Bone Joint Surg Am. 2022 May 4;104(9):759-766. doi: 10.2106/JBJS.21.01014. Epub 2022 Mar 14. PMID: 35286282.
  3. Ueyama H, Kanemoto N, Minoda Y, Taniguchi Y, Nakamura H. 2020 Chitranjan S. Ranawat Award: Perioperative essential amino acid supplementation suppresses rectus femoris muscle atrophy and accelerates early functional recovery following total knee arthroplasty. Bone Joint J. 2020 Jun;102-B(6_Supple_A):10-18. doi: 10.1302/0301-620X.102B6.BJJ-2019-1370.R1. PMID: 32475274.
  4. Baldissarro E, Aquilani R, Boschi F, Baiardi P, Iadarola P, Fumagalli M, Pasini E, Verri M, Dossena M, Gambino A, Cammisuli S, Viglio S. The Hip Functional Retrieval after Elective Surgery May Be Enhanced by Supplemented Essential Amino Acids. Biomed Res Int. 2016;2016:9318329. doi: 10.1155/2016/9318329. Epub 2016 Mar 24. PMID: 27110573; PMCID: PMC4823478.
  5. Kanae Nishizaki PT,, Hitoshi Ikegami MD, Yukio Tanaka MD, Ryutaro Imai MD, Hajime Matsumura MD, DMSc, FACS Effects of supplementation with a combination of β-hydroxy-β-methyl butyrate, L-arginine, and L-glutamine on postoperative recovery of quadriceps muscle strength after total knee arthroplasty Asia Pac J Clin Nutr 2015;24(3):412-420
  6. Dreyer HC, Strycker LA, Senesac HA, Hocker AD, Smolkowski K, Shah SN, Jewett BA. Essential amino acid supplementation in patients following total knee arthroplasty. J Clin Invest. 2013 Nov;123(11):4654-66. doi: 10.1172/JCI70160. Epub 2013 Oct 25. PMID: 24135139; PMCID: PMC3809795.
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  10. Kawada S, Kobayashi K, Ohtani M, Fukusaki C. Cystine and theanine supplementation restores high-intensity resistance exercise-induced attenuation of natural killer cell activity in well-trained men.J Strength Cond Res. 2010;24(3):846-851. doi:10.1519/JSC.0b013e3181c7c299
  11. Murakami S, Kurihara S, Koikawa N, et al. Effects of oral supplementation with cystine and theanine on the immune function of athletes in endurance exercise: randomized, double-blind, placebo-controlled trial.Biosci Biotechnol Biochem. 2009;73(4):817-821. doi:10.1271/bbb.80663
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  14. Dong Y, Zhang X, Miao R, et al. Branched-chain amino acids promotes the repair of exercise-induced muscle damage via enhancing macrophage polarization.Front Physiol. 2022;13:1037090. Published 2022 Dec 6. doi:10.3389/fphys.2022.1037090
  15. Fernández-Landa J, Fernández-Lázaro D, Calleja-González J, et al. Effect of Ten Weeks of Creatine Monohydrate Plus HMB Supplementation on Athletic Performance Tests in Elite Male Endurance Athletes.Nutrients. 2020;12(1):193. Published 2020 Jan 10. doi:10.3390/nu12010193 
  16. Fernández-Landa J, Fernández-Lázaro D, Calleja-González J, et al. Long-Term Effect of Combination of Creatine Monohydrate Plus β-Hydroxy β-Methylbutyrate (HMB) on Exercise-Induced Muscle Damage and Anabolic/Catabolic Hormones in Elite Male Endurance Athletes.Biomolecules. 2020;10(1):140. Published 2020 Jan 15. doi:10.3390/biom10010140
  17. Park HY, Kim SW, Seo J, Jung YP, Kim H, Kim AJ, Kim S, Lim K. Dietary Arginine and Citrulline Supplements for Cardiovascular Health and Athletic Performance: A Narrative Review. Nutrients. 2023 Mar 3;15(5):1268. doi: 10.3390/nu15051268. PMID: 36904267; PMCID: PMC10005484.
  18. Aquilani R, Zuccarelli Ginetto C, Rutili C, Pisano P, Pasini E, Baldissarro E, Verri M, Boschi F. Supplemented amino acids may enhance the walking recovery of elderly subjects after hip fracture surgery. Aging Clin Exp Res. 2019 Jan;31(1):157-160. doi: 10.1007/s40520-018-0941-x. Epub 2018 Apr 17. PMID: 29667153.
  19. Invernizzi M, de Sire A, D'Andrea F, Carrera D, Renò F, Migliaccio S, Iolascon G, Cisari C. Effects of essential amino acid supplementation and rehabilitation on functioning in hip fracture patients: a pilot randomized controlled trial. Agingu Clin Exp Res. 2019 Oct;31(10):1517-1524. doi: 10.1007/s40520-018-1090-y. Epub 2018 Dec 11. PMID: 30539540.
  20. Glenn JM, Gray M, Wethington LN, Stone MS, Stewart RW Jr, Moyen NE. Acute citrulline malate supplementation improves upper- and lower-body submaximal weightlifting exercise performance in resistance-trained females. Eur J Nutr. 2017 Mar;56(2):775-784. doi: 10.1007/s00394-015-1124-6. Epub 2015 Dec 11. PMID: 26658899.
  21. Dudgeon WD, Kelley EP, Scheett TP. In a single-blind, matched group design: branched-chain amino acid supplementation and resistance training maintains lean body mass during a caloric restricted diet. J Int Soc Sports Nutr. 2016 Jan 5;13:1. doi: 10.1186/s12970-015-0112-9. PMID: 26733764; PMCID: PMC4700774.
  22. Gwin JA, Church DD, Hatch-McChesney A, Howard EE, Carrigan CT, Murphy NE, Wilson MA, Margolis LM, Carbone JW, Wolfe RR, Ferrando AA, Pasiakos SM. Effects of high versus standard essential amino acid intakes on whole-body protein turnover and mixed muscle protein synthesis during energy deficit: A randomized, crossover study. Clin Nutr. 2021 Mar;40(3):767-777. doi: 10.1016/j.clnu.2020.07.019. Epub 2020 Jul 22. PMID: 32768315.
  23. Gwin JA, Church DD, Hatch-McChesney A, Allen JT, Wilson MA, Varanoske AN, Carrigan CT, Murphy NE, Margolis LM, Carbone JW, Wolfe RR, Ferrando AA, Pasiakos SM. Essential amino acid-enriched whey enhances post-exercise whole-body protein balance during energy deficit more than iso-nitrogenous whey or a mixed-macronutrient meal: a randomized, crossover study. J Int Soc Sports Nutr. 2021 Jan 7;18(1):4. doi: 10.1186/s12970-020-00401-5. PMID: 33413462; PMCID: PMC7791816.
  24. Coker RH, Miller S, Schutzler S, Deutz N, Wolfe RR. Whey protein and essential amino acids promote the reduction of adipose tissue and increased muscle protein synthesis during caloric restriction-induced weight loss in elderly, obese individuals. Nutr J. 2012 Dec 11;11:105. doi: 10.1186/1475-2891-11-105. PMID: 23231757; PMCID: PMC3546025.
  25. Moberg M, Apró W, Ekblom B, van Hall G, Holmberg HC, Blomstrand E. Activation of mTORC1 by leucine is potentiated by branched-chain amino acids and even more so by essential amino acids following resistance exercise. TAm J Physiol Cell Physiol. 2016 Jun 1;310(11):C874-84. doi: 10.1152/ajpcell.00374.2015. Epub 2016 Apr 6. PMID: 27053525.
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Xcelerated Recovery™

XR™ Therapeutic Musculoskeletal Recovery Supplement | 14-pack

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Formulation Highlights:

Vegan, Kosher, Sugar Free, Allergan & Nut Free, No added dyes or artificial flavors. 

Excellent source of Vitamin A, C, D3, B6, & Zinc.

The NSF Certified for Sport® Advantage:

Uncompromised Quality

Rigorously third party tested, and free from banned substances and contaminants, XR™ provides peace of mind.

Proven Efficacy

Certified effectiveness makes XR™ a recommended choice for pro athletes pursuing optimal performance and recovery.

Trusted by Professionals

XR™ is a preferred option for coaches, trainers, and healthcare professionals aiming for nutritional optimization and athletic excellence.

Parent-Approved Assurance

Trusted by parents of athletes, XR™ stands as a reliable and responsible option, ensuring the well-being and success of young athletes under their care.

NSF Certified for Sport®: Your Assurance of Quality and Safety

XR™ proudly bears the NSF Certified for Sport® certification, a hallmark of excellence recognized by premier sports organizations such as United States Anti-Doping Agency (USADA), MLB, NHL, NFL, NBA, Ironman, and many others. This rigorous third-party certification guarantees your safety and assures you that XR™ is free from contaminants and banned substances.

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