Total Knee Arthroplasty Surgery Recovery Research | Xcelerated Recovery™

XR® is currently conducting pilot studies evaluating the impact of targeted nutritional supplementation in Total Knee Arthroplasty healing and recovery.

Total Knee Arthroplasty Studies:

EAA Supplementation on Muscle Mass, Muscle Performance and Functional Capacity in Subjects Undergoing Total Knee Arthroplasty
Patients who received amino acid supplementation showed:
- 14% Increase in Isometric Knee Extension Strength
- 20% Less Quadriceps Atrophy (Ultrasound)
- 10% Faster Functional Recovery in TUG Test
- 6% Improvement in Serum Albumin Levels
(READ THE STUDY HERE)
EJOST 2024
Improved Functional Outcomes Post Total Knee Arthroplasty
Patients who received Essential Amino Acids (EAA) 1 wk pre-op and 2 wks post TKA had:
*2.2 - 4.6X Less quad and hamstring muscle loss (measured by MRI)
*30 - 55% Accelerated return of functional recovery post surgery
(READ THE STUDY HERE)
Dreyer Clin Invest. 2013
Faster Recovery in Total Knee Arthroplasty
Patients who received Essential Amino Acids 1 wk pre-op and 2 wks post-op showed:
*2 - 3X Faster Functional Recovery
*20% Less Quad Atrophy (ultrasound)
*17% Less Pain (VAS)
*6% Improved serum albumin
(READ THE STUDY HERE)
Ueyama Bone Joint J 2020
Preserved Muscle Mass Post Total Knee Arthroplasty
Patients who received EAA supplementation 1 wk pre-op to 6 wks post-op had significantly less muscle loss in both operated and contralateral leg.
Quadriceps:
*Operated leg -8.5% vs. -13.4%
*Contralateral leg -1.5% vs -7.2%
Hamstrings:
*Operated leg -7.4% vs -12.2%
*Contralateral leg -2.1% vs -7.5%
(READ THE STUDY HERE)
Dryer JBJS 2019
Enhanced Recovery Post Total Knee Arthroplasty
Patients who received HMB/Arg/Gln Supplementation for 5 days pre surgery and for 28 days post surgery showed:
*Significantly improved quad strength
*Improved muscle volume:
The control group lost 4.3% muscle volume lost after surgery
VS
The supplement group GAINED 10% muscle volume
(READ THE STUDY HERE)
Nishizaki J Clin Nutr 2015
Perioperative Essential Amino Acid Supplementation Facilitates Quadriceps Muscle Strength And Volume Recovery After TKA
Patients received EAA (9 g/day) supplementation from 1 week pre op to 2 weeks post op.
EAA group demonstrated significantly increased outcomes at 2 years after surgery.
*Rectus Muscle Area:
134% vs 114%
*Quad Muscle Area:
159% and 125%
(READ THE STUDY HERE)
Ueyama JBJS 2023
Commentary & Perspective
Nutritional Optimization with Amino Acid Supplementation Aids Recovery After Total Knee Arthroplasty
“Perioperative Essential Amino Acid Supplementation Facilitates Quadriceps Muscle Strength and Volume Recovery After TKA. A Double-Blinded Randomized Controlled Trial”
(READ THE COMMENTARY HERE)
Reviewed by: Golladay JBJS 2023