XR® is currently conducting clinical trials evaluating the impact of perioperative nutritional supplementation on hip fracture outcomes.

Nutritional status significantly impacts outcomes in geriatric patients:

  • >50% suboptimal nutritional status
  • 45% suffer from sarcopenia

Poor nutritional status is linked to:

  • Higher rates of complications
  • Longer hospital stays
  • Increased readmission and mortality after surgery

Targeted Nutritional Supplementation (TNS) helps:

  • Improve albumin levels
  • Reduce postoperative complications
  • Enhance recovery outcomes

Hip Fracture Studies:

  • ENHANCED RECOVERY POST HIP FRACTURE

    Essential Amino Acids (EAA) post surgery significantly improved functional recovery:

    62% Increase vs. control in 6-min walking distance test

    Aquilani 2018

    (CLICK HERE TO READ THE STUDY)

  • IMPROVED ALBUMIN & DECREASED INFECTION

    EAA supplementation post surgery resulted in:

    *42% Improvement in [Albumin]

    VS

    *25% Reduced infection rates

    Aquilani 2017

    (CLICK HERE TO READ THE STUDY)

  • IMPROVED RECOVERY POST HIP FRACTURE

    HMB supplementation post surgery led to improved body composition:

    *Preserved lean muscle mass

    *Improved functional recovery

    Maturitas 2017

    (CLICK HERE TO READ THE STUDY)

  • NUTRITIONAL SUPPLEMENTATION IMPROVES FUNCTION POST HIP FRACTURE

    EAAs in all sarcopenic patients demonstrated significant improvements in functional recovery outcomes:

    *71.9% of patients were sarcopenic

    Invernizzi 2019

    (CLICK HERE TO READ THE STUDY)

  • TNS POST HIP SURGERY PROMOTES EARLY REHAB WITH REDUCED COMPLICATIONS

    Supplemented patients had improved serum total protein and decreased complications:

    *Wound infection

    *Respiratory infection

    *Urinary tract infection

    Liu M 2015

    (CLICK HERE TO READ THE STUDY)

*References

  1. Bohl DD, Shen MR, Hannon CP, Fillingham YA, Darrith B, Della Valle CJ. Serum albumin predicts survival and postoperative course following surgery for geriatric hip fracture. J Bone Joint Surg Am 2017;99:2110–8
  2. Bachrach-Lindstrom M, Johansson T, Unosson M, Ek AC, Wahlstrom O. Nutritional status and functional capacity after femoral neck fractures: a prospective randomized one-year follow-up study. Aging (Milano) 2000;12:366–74
  3. Malafarina V, Reginster JY, Cabrerizo S, et al. Nutritional status and nutritional treatment are related to outcomes and mortality in older adults with hip fracture. Nutrients 2018;10:05
  4. Foss NB, Kehlet H. Mortality analysis in hip fracture patients: implications for design of future outcome trials. Br J Anaesth 2005;94:24–9
  5. Anbar R, Beloosesky Y, Cohen J, et al. Tight calorie control in geriatric patients following hip fracture decreases complications: a randomized, controlled study. Clin Nutr 2014;33:23–8
  6. Koren-Hakim T, Weiss A, Hershkovitz A, et al. The relationship between nutritional status of hip fracture operated elderly patients and their functioning, comorbidity and outcome. Clin Nutr 2012;31:917–21
  7. Cabrerizo S, Cuadras D, Gomez-Busto F, Artaza-Artabe I, Marin-Ciancas F, Malafarina V. Serum albumin and health in older people: review and meta analysis. Maturitas 2015;81:17–27
  8. Malafarina, Vincenzo et al. “Effectiveness of nutritional supplementation on sarcopenia and recovery in hip fracture patients. A multi-centre randomized trial.”Maturitasvol. 101 (2017): 42-50. doi:10.1016/j.maturitas.2017.04.010
  9. Malafarina V, Uriz-Otano F, Malafarina C, Martinez JA, Zulet MA. Effectiveness of nutritional supplementation on sarcopenia and recovery in hip fracture patients. A multi-centre randomized trial. Maturitas. 2017 Jul;101:42-50. doi: 10.1016/j.maturitas.2017.04.010. Epub 2017 Apr 22. PMID: 28539168.
  10. Willey MC, Owen EC, Miller A, Glass N, Kirkpatrick T, Fitzpatrick D, Wilken J, Marsh JL, Reider L. Substantial Loss of Skeletal Muscle Mass Occurs After Femoral Fragility Fracture. J Bone Joint Surg Am. 2023 Sep 22. doi: 10.2106/JBJS.23.00353. Epub ahead of print. PMID: 37738373.
  11. Invernizzi M, de Sire A, D'Andrea F, Carrera D, Renò F, Migliaccio S, Iolascon G, Cisari C. Effects of essential amino acid supplementation and rehabilitation on functioning in hip fracture patients: a pilot randomized controlled trial. Aging Clin Exp Res. 2019 Oct;31(10):1517-1524. doi: 10.1007/s40520-018-1090-y. Epub 2018 Dec 11. PMID: 30539540.
  12. Liu M, Yang J, Yu X, Huang X, Vaidya S, Huang F, Xiang Z. The role of perioperative oral nutritional supplementation in elderly patients after hip surgery. Clin Interv Aging. 2015 May 11;10:849-58. doi: 10.2147/CIA.S74951. PMID: 26005339; PMCID: PMC4433048.

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